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Phase 2: Cell Line Development and Process Development (Years 2-4) Simultaneously with analytical work, the developers manufacturing team constructs the expression system, typically a CHO (Chinese hamster ovary) cell line for monoclonal antibodies, and iterates upstream and downstream process parameters to hit the analytical target profile

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10.1038/s41409-019-0616-z 177 MerceronC.VinatierC.PortronS.MassonM.AmiaudJ.GuigandL.et al (2010)

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