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Research demonstrates that NNMT expression increases significantly with advancing age, particularly in metabolic tissues, contributing to the progressive decline in NAD+ levels observed during aging

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There is a regular feedback of errors from the DMC to the study sites

Beyond fat metabolism, the same fragment has been probed in unrelated tissues most notably a rabbit osteoarthritis model, where weekly intra-articular injection of AOD-9604, alone or with hyaluronic acid, improved cartilage scores relative to saline