l carnitine and hypothyroidism Frontiers Thyroid Thursday #76: Can Carnitine

KakarlaRKaruturiPSiakabingaQKasi ViswanathMDumalaNGuntupalliCet al

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Many oxidative electrophilic PTMs (e.g., cysteine oxidation at Cys151, Cys273 and Cys288) promote Nrf2 activation, leading to antioxidant gene induction, reduced ROS burden and limited TXNIP released from TRX thereby suppressing NLRP3 assembly

31 January 1915

48 The reduction could also be caused by loss of aminotransferases by filtration during hemodialysis or high lactate serum levels with consumption of NADPH resulting in subnormal aminotransferase levels

The reason for this strong correlation is that in general, p K a increases linearly with a G (g) ( r 2 0.70.95), as one would expect: higher a G (g) means a stronger HA bond, thus a weaker acid