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The trx-2 and trxr-2 genes comprise the mitochondrial thioredoxin system and are upregulated upon induction of the mitochondrial unfolded protein response (UPR mt ) [152,153]

For skin health applications, many experts prefer natural astaxanthin due to its potentially greater efficacy, though more comparative research is needed to definitively establish the differences in outcomes between natural and synthetic forms

Curcumin has demonstrated anti-inflammatory (130), antioxidant (131), wound-healing (132), and antimicrobial properties (133)

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Grandison RC, Piper MD, Partridge L

doi: 10.1186/s13148-019-0656-7

One of the best-studied oxidative DNA markers is 8-OH-Gua (Fig
