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No trials specifically enrolled elderly individuals, those with significant cardiovascular disease, individuals with active cancer, or pregnant/breastfeeding women

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Estimates vary widely - from about 2.6% of the global population (roughly 200 million people) to as high as 26% (over 2 billion) - depending on how deficiency is defined and measured

Acute subjective effects (improved focus, verbal fluency) are reported within 24 hours post-dose in some users, but structural synaptogenesis the mechanism underlying long-term cognitive enhancement requires 24 weeks of consistent dosing to produce measurable changes in memory or learning tasks