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Depending on their availability, certain metabolites can modify gene expression, protein function, and the epigenetic profile of the cell, ensuring a rapid adaptive response to changes in energy demand [1]

By activating several proteins involved in the TSS pathway and cystine uptake, including CBS, SLC7A11, GCLC, and GCLM, DMF increased GSH levels and produced a ferroptosis scavenging effect

Specifically, children with Crohns disease exhibit greater GPX and vitamin E concentrations than healthy controls, while plasma antioxidant concentrations are not significantly different between children with ulcerative colitis and healthy subjects [164]

It regulates lung cancer cell proliferation and ferroptosis mainly by inhibiting miR-299-3p and enhancing solute carrier family 38 member 1 (SLC38A1) expression [168]

One caution carries real weight

D., Rajagopal, L