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Using anti-angiogenic agents can potentially overcome the down-regulation of adhesion molecules and the unresponsiveness to inflammatory signals [314]
Marsh et al., 2012

Chwalisz K, Perez MC, Demanno D, Winkel C, Schubert G, Elger W

Linug Pauling Institute

Kruglikov IL, Scherer PE (2016) Dermal adipocytes: from irrelevance to metabolic targets

These disruptions can be due to inflammation, excessive dryness, or other pathological processes associated with skin diseases