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Importantly, this study also demonstrated that the B12 reduction associated with metformin use is not transitory but persists and progresses over time and, in some patients, to levels at which replacement is recommended
Christie, Oily Press, Dundee, 1997
doi: 10.1016/j.fct.2010.09.030
Moreover, the use of natural compounds as ferroptosis inhibitors may require a combination with established therapies or novel genetic approaches to enhance efficacy in the treatment of fibrosis
