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Cerebellar microglia may also experience metabolic stress, as observed in CSF1R-related leukoencephalopathy (CRL), a rare genetic disorder characterized by an autosomal dominant mutation in the CSF1R gene

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Without DAC, the peptide has a much shorter metabolic half-life in cellular models, allowing researchers to observe precise, acute spikes in pathway stimulation rather than a prolonged, continuous plateau

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