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However, that study demonstrated that in early disease these cells are located in zone 3 of the hepatic acinus, distal to the zone 1 iron-laden hepatocytes, implying hepatic stellate cells are activated into collagen-producing myofibroblasts by soluble mediators released from iron-damaged hepatocytes rather than by iron per s [75, 85]

[DOI] [PubMed] [Google Scholar] Schwarz J, Schumacher K, Brameyer Set al

Macrophages efficiently phagocytize the cells, but they failed to kill the fungus despite having ample ROS production

MicroRNA-184 Inhibits Cell Proliferation and Metastasis in Human Colorectal Cancer by Directly Targeting IGF-1R

[PubMed 10541033] 2401

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