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Zhang, J., Xue, R., Ong, W

While it is established that large-molecule cytokines, such as IL-17 and TGF-, play a role in immune regulation, small-molecule metabolites with molecular weights ranging from 50 to 1500 Da have the capacity to more readily penetrate cell membranes and modulate CD4 + T cell differentiation pathways

In the field of medicinal chemistry, adjusting functional groups allows for the manipulation of these properties to improve pharmacokinetic profiles

Flores-Rodriguez et al., 2011

2020 Holliday ZM, Earhart AP, Alnijoumi MM, Krvavac A, Allen LAH, Schrum AG

Users see an average weight drop of 11% at six months, climbing to 15% after a year of sticking with it