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Balanced nutrition: Pair with a protein-forward diet (1.62.2 g/kg bodyweight) to support lean mass retention during fat loss

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Mitochondrial fusion and fission in cell life and death

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Currently there are several small molecule agonists of GPR119 in clinical trials being tested for their efficacy in treating the hyperglycemia of type 2 diabetes as well as for their efficacy in treating obesity.

Concurrently, glucocorticoids can increase skeletal muscle resistance to anabolic regulators, such as IGF-1, promoting protein degradation while inhibiting protein synthesis, ultimately causing muscle atrophy