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It is a highly reactive metabolite that can accounts for majority of cyclophosphamide-induced organ toxicities by impeding with the body's antioxidant defense through generating reactive oxygen species (ROS) such as superoxide radicals, and hydrogen peroxide, and is considered the toxic moiety responsible for most of adverse effects of cyclophosphamide [9]

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You may be at risk if you: Are in the elderly age group Follow a vegetarian or vegan diet Have had stomach or intestinal surgery Suffer from digestive issues like celiac disease or Crohns disease Take acid-lowering medications like PPIs or H2 blockers Take metformin for diabetes Are pregnant or breastfeeding Sources of Vitamin B12 B12 is mainly found in animal-based foods : Meat, poultry, fish (especially liver) Eggs and dairy (milk, cheese, curd, paneer) Fortified cereals and plant-based milk (almond or soy milk) Note: B12 is not naturally found in plant foods , so vegetarians need to ensure they get it from dairy or fortified foods

doi: 10.3109/09513590.2012.683082 208 GonzlezF
