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When revisions are invited, a fact-based synthesis statement explaining their decision and outlining what is needed to prepare a revision will be listed below

500 The study revealed that patients receiving a single intravenous dose of ustekinumab (130 mg or 6 mg/kg) followed by a maintenance dose of 90 mg subcutaneously every 8 weeks experienced a significant reduction in symptoms such as rectal bleeding and no significant adverse events

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Yes, and in many cases, they should be

This applies to the kinetics of enzyme reactions and crucial measurements of the levels of metabolites

The changes in the ECD spectra (Figure 5 top right) are more prominent, especially the change in relative intensities of two negative bands in the 280 to 300nm region