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Prodrugs: Harnessing chemical modifications for improved therapeutics

Prx II-knockdown HaCaT cells were susceptible to H 2 O 2 -induced apoptosis mediated by Ca 2+ release from the endoplasmic reticulum through 1,4,5-triphosphate receptors (IP3Rs), the PI3K/AKT pathway and phosphorylated GSK3 (Ser9) were significant downregulated

Activation of wingless targets requires bipartite recognition of DNA by TCF

11 , e2102272 (2022)

Harrod A, Lai C-F, Goldsbrough I, Simmons GM, Oppermans N, Santos DB, et al

Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention