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Tockman MS, Comstock GW

The mechanism formally parallels the -elimination reaction catalyzed by PLP-dependant enzymes which accept cysteine thioethers as substrates and likely play a role in the renal toxicity and carcinogenicity of halogen-alkenes through their urinary metabolites [125]

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3.1 BDNF/Nrf2 signaling pathway Brain-derived neurotrophic factor (BDNF) is closely associated with clinical changes in depression, as indicated by meta-analyses linking BDNF levels to depressive disorders (Brunoni et al., 2008)