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International Classification Of Sleep Disorders 3rd edn (American Academy of Sleep Medicine, 2014)

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Based on the current literature, ASD involves many complex biological processes that manifest as physiologic and metabolic abnormalities

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Importantly, metabolic heatmaps show a reduction in the tumor-localized ratio of [1- 13 C]6PG to -[1- 13 C]gluconolactone at a timepoint (day 4) when tumor volume is unchanged, an effect that is retained at day 8 ( Figures 9DF )