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Mechanisms of resistance to anti-CD38 daratumumab in multiple myeloma

Mirpuri E, Garca-Trevijano ER, Castilla-Cortazar I, Berasain C, Quiroga J, Rodriguez-Ortigosa C, Mato JM, Prieto J, Avila MA

One trial used 2000 g/day vitamin B 12 and demonstrated a mean difference of 680 pg/mL (95% confidence interval 392.7 to 967.3) in favor of oral vitamin B 12

Deficiency in B12 can lead to demyelination, resulting in neurological symptoms such as numbness, tingling, impaired coordination, and cognitive decline

First thing in the morning

and low-risk patients (D/R) do not receive prophylaxis (5, 6)
