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Mouse models are highly effective in age related studies as the shortened timeline allows observation of the full impact of treatments in months as opposed to the years of human clinical trials

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It is designed to selectively disrupt the FOXO4-p53 interaction in senescent cells, enabling their targeted clearance while sparing healthy cells in preclinical models

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doi: 10.1038/NI.3766 114 StockAJGonzalez ParedesPde AlmeidaLPKosankeSDChetlurSBuddeHet al