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Arch Gen Psychiatry (2009) 66:84856

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It works through different pathways that don't directly conflict with the COX enzymes or angiogenesis in the same way NSAIDs do

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Nitrogen-containing Bisphosphonates Inhibit Isopentenyl Pyrophosphate Isomerase/farnesyl Pyrophosphate Synthase Activity with Relative Potencies Corresponding to Their Antiresorptive Potencies In Vitro and In Vivo