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10.1016/j.intimp.2013.07.005

This is consistent with the findings that overexpression of a mitochondrially targeted catalase decreases overall global disulfide bond formation (400), suggesting that these effects are due to the lack of mitochondrial oxidants and not other effects of GPx-1 overexpression (154)

You may consider clinical assessment if: Pigmentation is long-standing or resistant to topical care Melasma remains persistent despite conservative management Post-inflammatory hyperpigmentation does not gradually fade Sun damage is extensive Treatment recommendations should always be individualised after medical evaluation