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Neuron apoptosis pathway Prolonged OHP exposure induces the phosphoprotein 38 (p38) and extracellular regulated kinase 1/2 (ERK1/2) early activation, which promotes the apoptosis of DRG neurons, and the down-regulation of protective c-JunNH2-terminal kinase /stress activated protein kinase (JNK/Sapk), which increase OHP neurotoxic effects in vitro [96, 134]

48 This is in part because 2,3-diphosphogylcerate, an important regulator of the oxygen affinity of hemoglobin, is increased in PKD, which may enhance oxygen delivery

Additionally, they found that the GPX4 inhibitor RSL3 improves the anti-cancer effects of cisplatin by enhancing ferroptosis in vitro and in vivo (121, 122)

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