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Ma X, et al

Clinical Update 12/14/2017 Danger from Too Much Vitamin B6 A women who was consuming large amounts of an energy drink as well as a B-vitamin complex developed symptoms of vitamin B6 (pyridoxine) toxicity (which may not be reversible), according to a recent report
Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues

Am J Physiol Heart Circ Physiol (2012) 302(12):H261221

Some individuals may have a genetic predisposition to lower Glutathione levels, making supplementation beneficial for maintaining adequate antioxidant protection

On the opposite, urine volume is tightly controlled and serves as a way to tightly regulate the body fluid balance ( see part II.3 ), along with its other role of solute waste excretion
