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Within 3777 depression trials, the intervention studies were much more than the observational studies, and the number of interventional studies and observational studies were 3116 (82.50%) and 653 (17.29%), respectively

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That is, paralysis of smooth muscle contraction and reducing muscle tone or tension in the colon of laboratory animals has no detectable effect on stretch-activated firing of either class of enteric neuron 70,82,88

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