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11 Modafinil and armodafinil are FDA approved for use in narcolepsy and shift-work sleep disorder and have been noted to improve wakefulness/alertness and multiple sclerosisrelated fatigue, as well as residual daytime sleepiness in obstructive sleep apnea

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Given how much is circulating online some of it accurate, much of it overstated its worth laying out what the research actually shows, where the gaps are, and how we think about it clinically

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Vitamin K had the strongest correlation with the Average Change of the PGI-R, followed by biotin and lipoic acid

doi: 10.1093/brain/awy108 80 BissonJRChanKJSaferJD
