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Particularly in lean individuals or those with pre-existing low body fat

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Because AOD-9604 acts via adipocyte-specific pathways, primary adipocytes or 3T3-L1 differentiated cells are typical matrices of choice

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Signs of a severe allergic reaction (anaphylaxis) include: Skin rash, hives, or severe itching Swelling of the face, lips, tongue, or throat Difficulty breathing or wheezing A rapid heartbeat or a sudden drop in blood pressure If you ever develop swelling of the face or throat, trouble breathing, or other signs of a severe reaction after any injection, treat it as an emergency and call 911

The documented effects of microneedling itself include transient redness, pinpoint bleeding, temporary swelling, and, if done with poor hygiene, a risk of local infection