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Pyridoxine helps stabilize this signaling by ensuring adequate serotonin synthesis and metabolism, preventing the wild fluctuations that trigger nausea

150,151 The generation of reactive oxygen species is further augmented by decreased expression of the anti-oxidant enzymes superoxide dismutase 1 and 3 and isoforms of nitric oxide synthase

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The rationale for the possible use of MAO inhibitors in cessation of smoking, and their mechanisms of action
