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Vitamin B12 is a water-soluble vitamin, meaning excess amounts are generally excreted through urine rather than accumulating in the body to cause adverse gastrointestinal effects

21,22 Other mental health conditions often coexist with fibromyalgia, including bipolar disorder, generalized anxiety, and substance use disorder

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Natural processes make it reduce with age, or it can be delayed by poor diet, stress, and pollution

To further expand the set of SpyLock-based bispecific formats for screening, it should also be possible to combine SpyLock with knob-in-hole Fc domains, with the caveat that exposed disulfides in the hinge region should either be avoided or, alternatively, reoxidized after bispecific generation 40