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High levels of reactive oxygen species directly sensitize mast cells, altering their intracellular calcium levels and provoking them into inappropriate, constant degranulation

A3: Yes, due to its ability to promote healing in ligaments, tendons, and muscle tissue

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[DOI] [PMC free article] [PubMed] [Google Scholar] [60].Weiss N, Zhang YY, Heydrick S, Bierl C, Loscalzo J, Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction

Am J Hypertens 2008

In both conditions, the stimulation of the exchange protein directly activated by cAMP/Ras-related protein/phospholipase C signaling triggered a series of transcriptional events that ultimately led to Adrb3 gene repression