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At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

For best results, schedule weekly Lipo-C boosters and pair the treatment with B-12 injections to promote energy

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doi: 10.1172/JCI117320

These can include nervousness, headaches, or rapid heartbeat after taking methylcobalamin or methylfolate

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