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GSK-3 in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer

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Consumption of the non-nutritive sweetener stevia for 12 weeks does not alter the composition of the human gut microbiota

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For example, in pre-clinical studies, CB-839 demonstrated significant antiproliferative effects in the triple-negative breast cancer (TNBC) cell line HCC-1806 by markedly reducing glutamine consumption, glutamate production, and levels of several tricarboxylic acid cycle intermediates, as well as decreasing oxygen consumption and glutathione levels

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