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10.1016/j.biopha.2022.114086 [DOI] [PubMed] [Google Scholar] 18.Duan L, Cheng S, Li L, Liu Y, Wang D, Liu G

1,25(OH)2D inhibits T cell differentiation to Th1 type, reduces the secretion of inflammatory cytokines (IL-2, IFN-, TNF-), promotes Th2 differentiation and increases the secretion of inflammatory cytokines (IL-4, IL-5, and IL-10) (26)

Unlike ACD, which is touched off by overwhelming and uncontrollable accidental attacks and/or unexpected injuries, the occurrence of RCD depends on particular signals and precise molecular mechanisms, suggesting that RCD can be regulated via pharmacological or/and genetical approaches [10, 11]

The application of the ferroptosis inhibitor Fer-1 significantly reduces iron deposition, neuronal degeneration, and injury and improves the prognosis of patients, thus providing an experimental basis for TBI treatment targeting ferroptosis 75