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Description
As STING expression is limited in neoplastic cell populations of gliomas and other CNS tumors, the mechanism of action for STING agonists has mainly focused on immune-mediated anti-cancer activities

In the classic db/db mouse model of metabolic fatty liver, oral administration of betaine can inhibit the interaction between forkhead box protein O6 and peroxisome proliferator-activated receptor gamma (PPAR), inhibit the expression of primary lipogenic genes, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase, and reduce hepatic lipid accumulation (77, 78)

Thats not all we love it for, though

Their role in neuroprotection is primarily attributed to their ability to mitigate oxidative stress, reduce neuroinflammation, modulate neurotransmitter activity, and enhance neurogenesis (Butterfield and Halliwell 2019)

136 PerroneG.De GirolamoA.SarigiannisY.HaidukowskiM

Similarly, cytokines including IL-10, IL-33 and interferon- have been studied for their potential to suppress proinflammatory cytokine production and enhance memory 136
