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2019;31: e1801651

Saline was provided to control mice in the same volume

Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects

The questionnaire consisted of four questions: positive responses were scored as 13 points according to an abnormal degree, and negative responses were scored as 0 points (see Table 1)

The epidermal melanocytes are then stimulated to produce melanin as the tyrosinase inhibiting effect of GSH has been diminished.[9] So, the predominant mechanism of hyper pigmentation in vitamin B12 is hypothesised as 1) Deficiency of vitminB12 decreases the level of reduced glutathione, which activate tyrosinase and thus leads to transfer to melanosomes