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however, their role in ferroptosis remains speculative, primarily due to the limited number of studies that have investigated how surface functionalization alters iron release kinetics or ROS generation
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Another metabolic change is the decrease in the brains glucose uptake and glycolysis, which can be viewed as the early onset of AD (Ding et al., 2013

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Adv Pharmacol 2010
Wilson disease and other neurodegenerations with metal accumulations