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Mutations in genes crucial for LRO biogenesis are implicated in several inherited rare disorders developing co-existing symptoms of hypopigmentation, immunodeficiency, bleeding diathesis, and neuropathy (e.g., Hermansky-Pudlak Syndrome, Chediak-Higashi Syndrome, Griscelli Syndrome) 4,5

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In contrast, the prolonged disruption of normal sleep can contribute to neuroinflammation [168], norepinephrine-stimulated degeneration of the locus coeruleus, and hippocampal amyloid- 42 accumulation, with the potential to cause memory dysfunction and CD [169]

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6: 4166 Rose SJ, Stokes TC, Patel S, et al

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Rogers, Stenographer Wm

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