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Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promote albumindrug conjugate response

These findings have established peptides as credible research tools for probing the fundamental mechanisms of skin maintenance and repair

doi: 10.1172/jci.insight.140483 119 GonzalezCDCarro NegueruelaMPNicora SantamarinaCResnikRVaccaroMI

These include: - Fatigue - Irritability - Pale yellow tinge on the skin - Vision problems - Memory loss - Pins and needles or paraesthesia - Loss of physical co-ordination - Damage to parts of the nervous system

10.1158/1078-0432.CCR-15-0589 33 TomohiroN.SakamotoK

Downregulation of GS is not due to protein degradation but rather the inhibition of protein synthesis Since NH 4 Cl has previously been reported to induce autophagy in mouse embryo fibroblasts and tumor cells 17,18,19 , we wondered if GS downregulation in astrocytes upon glutamate and NH 4 Cl co-treatment was due to protein degradation