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Normally, this pore can be open for a short time

10.1073/pnas.1019581108 63

282 A subsequent open label study was conducted in 31 patients from the original study with persistently mild to markedly elevated liver enzymes

Most patients in the treatment group shifted from grade 2 or 3 to grade 0 or 1, which is defined as clear or almost clear as assessed by IGA scoring (Figure 2(d))

Nevertheless, the underlying evidence base has important limitations

Pharmacol Res 66(3):260268 Baker NA, English V, Sunkara M, Morris AJ, Pearson KJ, Cassis LA (2013) Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes