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Description
Toxic bile salts retention in the liver is accompanied by intracellular metabolic disorders, inflammation and reduced detoxification capacity [176], which may enhance the generation of oxidative stress and the accumulation of ROS and RNS in hepatocytes [177], leading to generalized systemic damage to major organs, starting from the liver and reaching the brain, heart, intestine, and kidney [178,179,180]

10.1016/j.freeradbiomed.2018.08.014 [DOI] [PMC free article] [PubMed] [Google Scholar] Rusetskaya N

Acknowledgements This work was supported by the Swedish Research Council and the Karolinska Institutet Center for Innovative Medicine
In 0.1 M RSL3-treated SK-Hep1 + cells, notable ROS or peroxidized lipid accumulation was seen which was abrogated by Fer-1 or Lip-1 (Fig

Conclusion and Future Directions The researchers emphasise that investigating TRPM3 dysfunction in ME/CFS and long COVID is essential for advancing our understanding of these conditions

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