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After being stimulated with phorbol myristate acetate and ionomycin, CD4 + cells from individuals with LC produced significantly higher median levels of intracellular IL-2 (17% (LC), 14% (CC) and 13% (HC)) and IL-4 (11% (LC), 7% (CC) and 8% (HC)) (Extended Data Figs

doi: 10.1152/ajprenal.00662.2009

These residues are highly conserved in all mammalian Sec-containing GPxs (see Fig

A hypothesized mechanism is attributed to L-cells that co-produce GLP-1 and GLP-2 at the same time, which regenerates intestinal epithelium, mediates peptide YY production, and subsequently, through appetite suppression, prolongs satiety through GLP-1 receptors and thus manages weight control [33, 47]

Targeted acquisition of MS/MS spectra (parallel reaction monitoring) was performed using an Orbitrap Fusion LUMOS instrument operated in targeted MS/MS mode using the Xcalibur software