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Acknowledgements The authors thank L Johnson, L Wilkins, S Bound, S Oliver, J Martin, R Meeny, N Blasch, and F Dabrowski for animal care, S Holloway and J House for veterinary care, L Potenza and C Burstrm for excellent technical assistance, and A Samson for insightful advice

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Response of brain amino acid metabolism to ketosis

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Under conditions of cellular stress, including ER stress (via the UPR), cytosolic protein aggregation, starvation, and infection, the ISR is activated to restore cellular homeostasis [224]

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ESMO, on the other hand, could not reach a consensus on the benefits regarding methylphenidate, but advocates shorter courses of corticosteroids in patients with metastatic cancer [31]

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L-Carnitine helps the body turn fat into fuel

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As an alternative drug delivery route, topical medications have not shown promising results and need further evaluation in future trials

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