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The results of a sequential supplementation trial in 53 men and women indicated that after optimization of folate status with folic acid supplements, vitamin B 12 became the major determinant of plasma homocysteine levels (30)

Research demonstrates thymosin beta-4 was identified as a gene upregulated 4-6-fold during early blood vessel formation and promotes growth of new blood cells from existing vessels

Or they may find themselves B12 deficient for other reasons

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