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Piperine may also interfere with efflux drug transporters and phase I cytochrome P450 enzymes and increase the bioavailability and slow the elimination of a number of drugs, including phenytoin (Dilantin), propranolol (Inderal), theophylline, and carbamazepine (Tegretol) (121-123)

Consequently, it preserves glucose needed for energy production within the liver, converting it into glycogen, which is stored for future energy requirements

However, large-scale, multicenter studies are needed to be confirm theses associations

343 YamashitaT.NakaoY.MatsunagaS.OikawaT.ImaharaY.FusetaniN

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