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doi: 10.1038/nchembio.2239 68 DixonSJWinterGEMusaviLSLeeEDSnijderBRebsamenMet al

Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells

Cisplatin resistance associated with PARP hyperactivation

We evaluated this in the context of non-small cell lung cancer (NSCLC), given its sensitivity to cysteine starvation 24 and the robust mitochondrial metabolism exhibited by human lung tumors 25,26