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[21] After the solution is deposited into muscle, cholecalciferol diffuses into the circulation bound to vitamin-D-binding protein and undergoes 25-hydroxylation in hepatocytes, yielding 25-hydroxyvitamin D, the principal circulating biomarker of status

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Patients who have a severe deficiency will notice the results earlier than patients with a mild deficiency

That could change after the committee review in July 2026, but today, it's not approved

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