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It is proposed that the function of the nonpolar, aminoacyl side chain is to guide oxygen at the site where it subsequently will be activated to a superoxide species through electrostatic catalysis exerted by a positive charge 53

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Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1

Neurotrophic agents such as nerve growth factor and brain-derived neurotrophic factor have received research attention concerning their potential to treat AD but have not progressed to clinical trials due to their reasonably large size, inability to penetrate the blood-brain barrier (BBB), and the high cost of synthesis