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doi: 10.1161/JAHA.116.005465 40 Nagy-SzakalDBarupalDLeeBCheXWilliamsBKahnEet al
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A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)
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