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Importantly, in our previous research, we found that SIRT1 knockdown mice ( SIRT1 +/- mice) exhibits significant pre-eclampsia-like performances, such as hypertension, proteinuria, fetal growth restriction, kidney injury, and narrow labyrinthine layer, while the manifestations could be reversed after intraperitoneally injecting SRT2104, which is a highly selective agonist of SIRT1[17]

Trazodone did not affect on both complex I and complex IV [204], but decreased oxygen consumption and reduced Na + , K + -ATPase activity

Then the pellets were stained for 20 min in 100 l assay buffer containing 5 g ml 1 propidium iodide (Sigma-Aldrich, P4170) and 3 l Annexin VFITC (BioLegend, 0640906)

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BMC Med Res Methodol

Biosensors 2025 , 15 , 120