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In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye in an ear meets a long standing need for suitable testing methods that are applicable to the development of intratympanic otic formulations or compositions suitable for human use

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Similarly, both groups exhibited significantly shorter escape distances than did the control group ( P = 0.0259 for the combination group and P = 0.0291 for the standard drug group

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