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Multiple lung conditions, such as chronic obstructive pulmonary disease (COPD), acute/chronic lung injury, and radiation-induced and immune checkpoint inhibitor-related lung injury, can lead to PF [8, 9]

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Multiple studies have found that patients receiving cortisone injections often experience worse outcomes at 6 and 12 months compared to those who received placebo injections or physical therapy alone

10.1016/j.ijbiomac.2019.08.149 33 LippiG.FranchiniM.TargherG

Peripheral administration of an angiotensin II AT(1) receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation Stress

Chronic antigen stimulation and persistent TCR signaling upregulate death receptors such as Fas (CD95) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors on activated T cells, increasing their susceptibility to activation-induced cell death (AICD) [304]